Irreversible Liver Failure

Irreversible renal failure following mefenamic acid.

Liver Failure and Liver Disease

Cirrhosis with ascites is associated with impaired renal function accompanied by sodium and water retention. Although it has been suggested thatmediators such as nitric oxide play a role in the development of renal failure in this situation, other mechanisms underlying the process are not well understood. This study examined the role of oxidative stress in mediating renal damage during the deve...

LIVER FAILURE AND LIVER DISEASE LIVER FAILURE Acetaminophen-Induced Acute Liver Failure: Results of a United States Multicenter, Prospective Study

Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen-induced ALF at 22 tertiary care centers in the United States. Detailed prospective data were gathered on 662 consecutive patients over a 6-year period fulfilling standard criteria for ALF (coagulopathy and encephalopathy), from which 275 (42...

Small intestinal transplantation for irreversible intestinal failure in children.

Permanent intestinal failure, whether secondary to severe gastrointestinal tract dysfunction or short bowel syndrome, remains a challenging pediatric health problem that requires innovative therapeutic modalities. Steatorrhea and intractable diarrhea result in failure to thrive, hypovitaminosis, hypoproteinemia, electrolyte disturbance, and metabolic acidosis if parenteral alimentation (TPN) is...

An update on irreversible electroporation of liver tumours.

OBJECTIVE. To investigate the clinical efficacy and safety of irreversible electroporation for ablation of liver tumour in humans. DATA SOURCES. The PubMed and MEDLINE databases were systematically searched. STUDY SELECTION. Clinical research published in English in the last 10 years until October 2013 that address clinical issues related to irreversible electroporation of human liver tumours w...